Advances in Biosciences Seminar - Dr Daniel Wehner "Axon regeneration in the vertebrate CNS - a matter of ECM composition, structure and mechanics"
| Dates: | 20 February 2024 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff |
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| Speaker: | Daniel Wehner |
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Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in humans and other mammals, whereas it facilitates axon regeneration in the zebrafish. However, the molecular basis of these differential fates is not understood. In my presentation, I will provide evidence that the specific biochemical composition of injury-induced ECM determines regenerative success. I will report on a cross-species comparison that lead to the identification of members of the small leucine-rich proteoglycan family as new ECM factors, which drive CNS healing toward inhibitory scarring by conferring mechanical properties to the lesion environment adverse to axon regeneration.
Biosketch:
Daniel Wehner received his PhD at Ulm University (Ulm, Germany), where he studied mechanisms of tissue regeneration using the zebrafish fin as a model system. He then conducted his postdoctoral studies at the University of Edinburgh (Edinburgh, United Kingdom) and Technische Universität Dresden (Dresden, Germany), focusing on mechanisms of central nervous system (CNS) regeneration in zebrafish. Since 2019, Daniel Wehner has been leading the Neuroregeneration Research Group at the Max Planck Institute for the Science of Light and the Max-Planck-Zentrum für Physik und Medizin in Erlangen (Germany). His current research focuses on elucidating the principles of functional axon regeneration in the vertebrate CNS, with a particular emphasis on the extracellular matrix. His goal is to inform research in non-regenerating systems.
Speaker
Daniel Wehner
Role: Dr
Organisation: Max Planck Institute
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Michael Smith Lecture Theatre
Michael Smith Building
Manchester
