Chay Paterson -- Network models of carcinogenesis in colorectal adenocarcinoma and vestibular schwannoma
|Starts:||14:00 4 Apr 2022|
|Ends:||15:00 4 Apr 2022|
|What is it:||Seminar|
|Organiser:||Department of Mathematics|
|Who is it for:||University staff, External researchers, Current University students|
Join us for this seminar by Chay Paterson (Manchester) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. Details of the full series can be found here https://www.cms.livjm.ac.uk/APMSeminar/
The talk will be hosted in Simon Building room 4.05 and via zoom, please contact firstname.lastname@example.org or email@example.com for the zoom link, or sign up to the mailing list.
Abstract: Multi-stage mathematical models have contributed a great deal to our understanding of cancer, from Armitage and Doll's original work in the 1950s, to Knudson's studies of retinoblastoma in the 1970s. We extend these models from linear paths to networks with multiple mutational pathways: somatic evolution is understood as a stochastic process on a directed graph, with edges representing specific mechanisms. This approach links population incidence, genomic data, and molecular mechanisms.
While originally developed for colorectal adenocarcinoma, when applied to vestibular schwannoma, our approach enables new estimates of mutation rates in Schwann precursor cells. We also try to constrain what events may trigger the extremely rare process of malignant transformation of vestibular schwannoma. I make the case that this class of tumours represents an exciting opportunity to study tumour initiation and malignant transformation "in slow motion" and high resolution, with evolutionary models on networks providing us with powerful analytic tools.
To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to firstname.lastname@example.org
Role: Honorary Postdoctoral Associate
Organisation: University of Manchester
Travel and Contact Information
4.05 (and via zoom)