Macrophages: the conductors of white matter regeneration
| Dates: | 3 November 2015 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Dr Veronique Miron |
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The regeneration of myelin following central nervous system injury fails in disorders of development (perinatal brain injury; cerebral palsy) and adulthood (multiple sclerosis), highlighting the need to understand the cellular mechanisms underpinning successful myelin repair in order to develop novel therapeutic approaches. Our research underscores the critical role of macrophages in driving this regenerative process, by showing i) temporal regulation of macrophage activation controls specific phases of stem cell responses during repair, ii) this involves complementary yet distinct functions of endogenous macrophages (microglia) and circulation-derived macrophages, iii) a dysregulation of this macrophage activation switch prevents myelin repair, and manipulating macrophage activation can promote repair, and iv) identifying novel regenerative macrophage-derived factors that can represent therapeutic targets to treat myelin disorders.
Speaker
Dr Veronique Miron
Organisation: University of Edinburgh
Travel and Contact Information
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Michael Smith Lecture Theatre
Michael Smith Building
Manchester
