Integrin traffic and mechanosensing in cancer
| Dates: | 22 September 2015 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Professor Johanna Ivaska |
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Integrins are a family of transmembrane cell-surface molecules that constitute the principal adhesion receptors for the extracellular matrix, and are indispensable for the existence of multicellular organisms. Dynamic remodelling of adhesions, through rapid endo/exocytic trafficking of integrin receptors, is an important mechanism employed by cells to regulate integrin-ECM interactions during processes such as cell migration, invasion and cytokinesis. In addition, integrins function as important mechanotransducers in cellular mechanosensing. In my talk I will discuss two recently emerged concepts in my laboratory: Endosomal inside-in signalling of integrins in promoting anoikis resistance and metastasis and how tumor stroma crosstalk regulates carcinoma cell proliferation.
Speaker
Professor Johanna Ivaska
Organisation: University of Turku
Travel and Contact Information
Find event
Michael Smith Lecture Theatre
Michael Smith Building
Manchester
