Mitchell Centre Seminar Series: Adam Stevens
|Starts:||16:00 27 May 2015|
|Ends:||16:00 27 May 2015|
|What is it:||Seminar|
|Organiser:||School of Social Sciences|
Adam Stevens, University of Manchester
Network analysis in the study of gene:environment interactions: the integration of genomic, environmental and social data
The interactions between living creatures and their environments are primary determinants of health. Variation within the genome of living creatures ensures inter-individual differences in gene: environment interfaces and these manifest in the levels that genes are expressed (transcriptome) and the products of the genes (proteome and metabolome). As genetic information is fixed models of transcriptomic, metabolomic and proteomic data represent a unique window into the mechanisms by which gene and environment interact. Many types of social measurements reflect the interaction between genes and local environment. At the moment ‘omic datasets are underused in the study of how biology and social/environmental parameters interrelate.
In this talk an overview of the field will be presented highlighted by two main examples. The first looking at environmental interaction with growth response in children where both genetic and transcriptomic data were used to assess the effect. The second is from work that has linked genetic markers with the assessment of frailty in later life. Network approaches were used in both examples to assess models of genetic and transcriptomic data identifying both hierarchical clusters of genes and short chains of related function.
The use of network analysis to link genetic, transcriptomic, environmental and social effects forms a basis to study gene: environment interactions with a new level of detail.
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