Phenotypes in Homeostasis: The Tissue Stiffness as a Paradigm
|Starts:||11:00 14 Mar 2018|
|Ends:||12:00 14 Mar 2018|
|What is it:||Seminar|
|Organiser:||Faculty of Biology, Medicine and Health|
|Who is it for:||University staff|
Molecular circuits that allow self-regulating biological systems to maintain stability while adjusting to conditions mediate adaptation, survival and health. Thus, if homeostasis is successful, life continues; if unsuccessful, diseases emerge. My laboratory focuses in understanding how phenotypes are in homeostasis, and the RNA based molecular mechanisms that sustain them.
We used multidisciplinary approaches that combines genome wide analysis of cells in different substrates rigidity and biomechanical tests in vivo. We discovered that in stiff substrates cytoskeleton-adhesion-matrix (CAM) genes are co-expressed and regulated by their paired miRNAs. The miRNA-mRNA CAM network is the first “negative regulator” proposed to establish tissue stiffness homeostasis.
Role: Assistant Professor
Organisation: School of Medicine, Yale University
Travel and Contact Information
Michael Smith Building