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Dynamic models of cellular metabolism – an uncertain perspective

Dates:20 February 2014
Times:09:00 - 10:00
What is it:Seminar
Organiser:Faculty of Life Sciences
Who is it for:University staff, Current University students
Speaker:Rainer Breitling
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Dynamic models of metabolism are powerful tools to understand cellular biology, develop medical interventions to treat disease, and to help engineering biological systems with new functionalities. The quality of the model predictions depends on the reliability of the kinetic parameter information used to construct the models. However, in contrast to other areas, such as climate modelling, the uncertainty of parameter information is rarely systematically explored in biological models of metabolism. In my talk I will present our work on the explicit incorporation of parameter uncertainty in systems biology and illustrate it using examples from central energy metabolism in protozoan parasites. I will also discuss applications in other areas of systems biology, such as the modelling of signal transduction pathways, and in synthetic biology.

A Gene Regulation and Cellular Biotechnology Science for Breakfast seminar. Contact Graham Pavitt for further information.

Speaker

Rainer Breitling

Organisation: Manchester Institute of Biotechnology

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1.006
AV Hill Building
Manchester

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Professor Graham Pavitt

0161 275 64477

graham.pavitt@manchester.ac.uk

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