MIB Seminar - 'Scarless, allele-specific and sub-Mb-scale engineering to the human genomes' - Professor Yasunori Aizawa
|Dates:||8 March 2023|
|Times:||13:00 - 14:00|
|What is it:||Seminar|
|Organiser:||Faculty of Biology, Medicine and Health|
|Who is it for:||University staff, Current University students|
Professor Yasunori Aizawa is visiting the MIB on Wednesday 8 March to deliver a seminar entitled 'Scarless, allele-specific and sub-Mb-scale engineering to the human genomes'
Our group recently developed a genome engineering platform for cells having long, diploid and repeat-rich genomes such as human cells, called Universal Knock-in System or UKiS (Nature Communications 13, 4219, 2022). UKiS allows for precise substitution of sub-megabase-scale regions into synthetic genomic sequences of our desire in biallelic and scarless manners even in human induced pluripotent stem cells (iPSCs); both alleles of your interest in autosomes can be efficiently modified and tags or markers disturbing downstream analyses or purposes are not left at the engineered regions. UKiS has potential to expand our capability of multi-functionalization of human cell for various industrial uses including therapeutic one. In this presentation, I will introduce our latest applications of UKiS and the other engineering tools that we have established for investigating functional meanings of the noncoding genomic regions as well as for creating human cells for drug screening, disease study cells and therapeutic modality development.
If anyone would like to meet personally with Yas during his visit, please contact email@example.com
Travel and Contact Information
MIB Lecture Theatre
Manchester Institute of Biotechnology - John Garside Building