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Lloyd Bridge -- Modern receptor theory and low-dimensional models for binding and signal transduction in mathematical pharmacology [ONLINE]

Patterned pufferfish scales demonstrating a Turing pattern in the natural world
Dates:18 September 2024
Times:13:00 - 14:00
What is it:Seminar
Organiser:Department of Mathematics
Who is it for:University staff, External researchers, Current University students
Speaker:Lloyd Bridge
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  • Mathematics in the life sciences
  • Department of Mathematics

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  • In category "Seminar"
  • In group "(Maths) Mathematics in the life sciences "
  • In group "(Maths) Maths seminar series"
  • By Department of Mathematics

Join us for this seminar by Lloyd Bridge (Bristol) as part of the North West Seminar Series in Mathematical Biology and Data Science. More details about the joint series can be found here https://northwestseminars.great-site.net/ .

The talk will be hosted by the University of Liverpool and available to watch via zoom. Please contact carl.whitfield@manchester.ac.uk or mdomijan@liverpool.ac.uk for the link, or sign up to the mailing list.

Title: Modern receptor theory and low-dimensional models for binding and signal transduction in mathematical pharmacology

Abstract: Analytical pharmacology stems from concepts underlying classical receptor theory. Many classical assumptions (e.g. monomeric receptors, and single ligand-induced pathway activation) are insufficient to model, understand and exploit the diversity of cellular signalling of pharmacological interest. Here, we present results from recent interdisciplinary work which updates the classical theory. We further outline new directions in the recognised and growing field of mathematical pharmacology, encompassing detailed cell signalling models and compartment models in pharmacokinetics.

The mathematical modelling and analysis in this talk includes linear and nonlinear ODE models, structural identifiability analysis and asymptotic analysis. The talk is designed to be accessible to graduate students.

To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk

Speaker

Lloyd Bridge

Role: Senior Lecturer

Organisation: UWE Bristol

  • https://people.uwe.ac.uk/Person/LloydBridge

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Carl Whitfield

carl.whitfield@manchester.ac.uk

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