Bindi Brook -- Airway remodelling in asthma and tissue destruction in emphysema - two sides of the same coin? [IN PERSON]
| Dates: | 1 December 2025 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Bindi Brook |
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Join us for this seminar by Bindi Brook (Nottingham) as part of the Maths in the Life Sciences seminar series (and the online North West Seminar Series in Mathematical Biology and Data Sciences in collaboration with Liverpool Universities).
Title: Airway remodelling in asthma and tissue destruction in emphysema - two sides of the same coin?
Abstract: Inflammation, airway hyper-responsiveness (which causes constriction of the airways at lower trigger levels than in normal subjects) and airway remodelling (long term structural changes of the airway wall) are key features of asthma. While this is well-established, it is not clear how they are linked or whether they are causes or symptoms of the disease. In this talk I will describe a theoretical multiphase morphoelastic model of asthmatic airways, developed in parallel with an experimental study (aimed at addressing these questions) and present some illustrative results. The model accounts for interactions between biological processes and tissue mechanics allowing us to examine (i) the effect of remodelling on the mechanical properties of the airways, and (ii) how a simple mechanical feedback mechanism may enable homoeostasis to be maintained in healthy airways.
Finally (time-permitting) I will briefly describe results of some preliminary models of parenchymal tissue destruction in emphysema, again linking biological processes with mechanical stress, but this time in a vertex-based spring network mimicking parenchymal tissue.
The talk will be also be streamed via Teams, please contact carl.whitfield@manchester.ac.uk or igor.chernyavsky@manchester.ac.uk for the zoom link, or sign up to the mailing list.
To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk
Speaker
Bindi Brook
Role: Professor
Organisation: University of Nottingham
Travel and Contact Information
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G.43
Williamson Building
Manchester
