Advances in Biosciences Seminar - Adam Grieve "Sharpening cell surface signalling through rhomboid intramembrane proteolysis"
| Dates: | 14 November 2023 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff |
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| Speaker: | Dr Adam Grieve |
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Dr Adam Grieve is a Research Fellow at Bristol University whose research interests cover:
The function of signalling receptors, transporters and channels in the plasma membrane is essential for all living cells. Their biological importance is highlighted by the observation that ~70% of clinical drugs target integral membrane proteins and that even subtle mutations or defects in their activity lead to human disease.
The major goal of our group is to define the molecular mechanisms for integral membrane protein regulation within the plasma membrane. In particular, we focus on relatively unexplored regulators – such as intramembrane proteases – that have the ability to “read” and respond to the dynamics of transmembrane domains of receptors, channels and transporters.
We anticipate that our study of proteostasis and quality control of membrane proteins will shed light on the molecular basis of neurodegenerative disorders and cancer.
Speaker
Dr Adam Grieve
Role: Research Fellow
Organisation: University of Bristol
Travel and Contact Information
Find event
Michael Smith Lecture Theatre
Michael Smith Building
Manchester
