Celebrating FLS Research Success: mRNA selection for translation: new perspectives on the cytosolic site of translation and the machinery involved

Dates:	4 September 2015
Times:	15:00 - 16:00
What is it:	Seminar
Organiser:	Faculty of Life Sciences
Who is it for:	Current University students, University staff
Speaker:	Dr Mark Ashe

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The next seminar in the ‘Celebrating Research Success in FLS’ series will be given by Dr Mark Ashe, who is a member of the Computational and Evolutionary Biology (CEB) Research Theme (sub theme: Functional Genomics and System Biology). The seminar will take place on Friday 4 September, 3-4pm, in Michael Smith Lecture Theatre. The seminar is scheduled to take place just prior to FLS Happy Hour to allow discussions and networking to continue after the actual presentation.

Mark’s presentation will be entitled ‘mRNA selection for translation: new perspectives on the cytosolic site of translation and the machinery involved’ and will focus on two of his publications:

Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PF, Grant CM, Pavitt GD, Hubbard SJ, Ashe MP. 2015. Global mRNA selection mechanisms for translation initiation. Genome Biol. 16: 10.
Lui J, Castelli LM, Pizzinga M, Simpson CE, Hoyle NP, Bailey KL, Campbell SG, Ashe MP. 2014. Granules harboring translationally active mRNAs provide a platform for P-body formation following stress. Cell Rep. 9: 944-54.

Abstract Two recent studies from the lab have challenged current perceptions as to how individual mRNAs are translated. Firstly, we have found that some heavily translated mRNAs that encode cytosolic proteins are localised to specific foci while being translated, and have started to explore potential reasons for this localised translation. Secondly, the machinery responsible for selecting mRNAs for translation interacts poorly with these localised mRNAs even though hey are heavily translated. These results have highlighted a potential role for localised mRNA translation in the co-regulation or folding of nascent proteins in the same complex or pathway, and in the inheritance of key mRNAs during the cell cycle.