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Targeting the Hyaluronan-Based Extracellular Matrix to Reverse Neurodegenerative Disease

Dates:7 March 2019
Times:13:00 - 14:00
What is it:Seminar
Organiser:Faculty of Biology, Medicine and Health
Who is it for:University staff, Current University students
Speaker:Larry Sherman
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  • In category "Seminar"
  • By Faculty of Biology, Medicine and Health

The glycosaminoglycan hyaluronan (HA) is elevated in the central nervous system (CNS) following a number of insults including neurodegenerative diseases. We have found that this HA is digested into fragments in damaged CNS tissues through the actions of hyaluronidases. These fragments signal in neural progenitor cell populations through a non-canonical toll-like receptor 4 pathway that alters both neuronal and glial cell gene transcription. Increased hyaluronidase activity in the hippocampus leads to alterations in adult neurogenesis and cognitive function, while in white matter, hyaluronidase activity blocks the maturation of progenitors involved in nervous system repair. We recently identified novel hyaluronidase inhibitors and demonstrated that these agents can promote nervous system repair in models of human neurodegenerative diseases. These agents are now being tested in pre-clinical trials.

Speaker

Larry Sherman

Role: Professor

Organisation: Oregon Health and Science University

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