Magdalena Strauss -- Statistical modelling of heterogeneous response to perturbations in single cells [ONLINE]
| Dates: | 11 September 2024 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Magdalena Strauss |
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Join us for this seminar by Magdalena Strauss (Exeter) as part of the North West Seminar Series in Mathematical Biology and Data Science. More details about the joint series can be found here https://northwestseminars.great-site.net/
The talk will be hosted by the University of Liverpool and available to watch via zoom. Please contact carl.whitfield@manchester.ac.uk or mdomijan@liverpool.ac.uk for the link, or sign up to the mailing list.
Title: Statistical modelling of heterogeneous response to perturbations in single cells
Abstract: Individual cells respond to perturbations such as disease, drugs, or gene editing (experiments that change DNA) at different speeds, to different degrees or using different cellular response mechanisms. Understanding this inter-cell heterogeneity is vital in applications to precision medicine. Experimentally, single-cell methods such as single-cell RNA-sequencing and single-cell DNA-sequencing have paved the way for a fine-grained understanding of the heterogeneity of cellular response to perturbations. However, high noise levels and biases in the data have required the development of specific statistical tools for data analysis and to inform experimental set-up.
I will be presenting a joint effort with experimental research groups to develop an approach that links DNA, RNA and drug response in single cells. Our approach has enabled the systematic study of rare DNA mutations in patients at scale in the lab. We then applied this strategy to improve understanding of mechanisms of resistance to cancer drugs.
To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk
Speaker
Magdalena Strauss
Organisation: University of Exeter
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