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The role of type IV collagens in human disease – multiple organs, multiple mechanisms

Dates:23 January 2023
Times:12:00 - 13:00
What is it:Seminar
Organiser:Faculty of Biology, Medicine and Health
Who is it for:University staff, Current University students
Speaker:Douglas Gould
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  • In category "Seminar"
  • By Faculty of Biology, Medicine and Health

Abstract: Collagen IV alpha 1 (COL4A1) and alpha 2 (COL4A2) are primordial extracellular matrix proteins that are core components of basement membranes in all organs. COL4A1 and COL4A2 mutations cause a multi-system disorder for which cerebral small vessel disease is a major consequence. We use genetic approaches to understand the mechanisms by which COL4A1 and COL4A2 cause defects during developmental angiogenesis and age-related cerebrovascular dysfunction.

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https://zoom.us/j/92632334929 Passcode: 789416

Speaker

Douglas Gould

Role: Professor

Organisation: University of California, San Francisco

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Lecture Theatre
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Anna Fildes

anna.fildes@manchester.ac.uk

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