Centre for Primary Care & Health Services Research Seminar: Dr Kym Snell - External validation of existing prediction models for pre-eclampsia and development of new models using an IPD meta-analysis
| Dates: | 15 December 2020 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Dr Kym Snell |
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At this seminar, our external speaker Dr Kym Snell, Lecturer in Biostatistics at Keele University, will present a talk titled “External validation of existing prediction models for pre-eclampsia and development of new models using an individual participant data (IPD) meta-analysis”.
Summary:
Pre-eclampsia is a condition that can occur in the second half of pregnancy and is a leading contributor to maternal and perinatal mortality and morbidity. Accurately predicting which women are at high risk of pre-eclampsia would enable effective antenatal care to reduce the risk of developing pre-eclampsia and the adverse outcomes associated with it. Over 130 models have been developed for predicting pre-eclampsia, yet few have been externally validated and none are currently recommended by guidelines.
The International Prediction of Pregnancy Complications (IPPIC) collaborative network consists of 125 collaborators from 25 countries, many of whom have contributed individual participant data (IPD) from primary studies. The IPPIC database contains IPD from over 70 studies and over 5 million women with information on clinical characteristics, biochemical markers, ultrasound markers as well as maternal and offspring complications.
In this talk I will discuss how we externally validated existing prediction models, and developed and validated new prediction models for pre-eclampsia using an IPD meta-analysis approach with the IPPIC data. The talk is intended for a wide audience, and will discuss issues such as missing data, meta-analysis methods for summarising predictive performance, dealing with between-study heterogeneity, and examining clinical utility.
For Zoom details, please email: CPC.seminar.series@manchester.ac.uk
Speaker
Dr Kym Snell
Role: Lecturer in Biostatistics
Organisation: Centre for Prognosis Research, School of Primary, Community and Social Care, Keele University
Travel and Contact Information
