How the mouse gets its tail: role of neuromesodermal stem cell-like progenitors in axis elongation
| Dates: | 14 February 2014 |
|---|
| Times: | 14:00 - 15:00 |
|---|
| What is it: | Seminar |
|---|
| Organiser: | Faculty of Life Sciences |
|---|
| Who is it for: | University staff |
|---|
| Speaker: | Val Wilson |
|---|
|
|
This seminar is part of the Manchester Tissue Regeneration & Stem Cell Network seminar series. The Wilson lab identified a bipotent population of progenitors for the anteroposterior axis in mouse, neuromesodermal (NM) progenitors, and showed that these cells are bipotent stem cell-like progenitors. Current research focuses on the factors that control maintenance and differentiation of these cells, using experimental embryology techniques (embryo microdissection, grafting and culture), as well as cell culture of pluripotent cell lines, to investigate whether developmental cues identified in the embryo can be used to propagate NM progenitor cells in vitro, and control their differentiation. I will present our recent data using in vitro epiblast stem cell lines and embryo micromanipulation to elucidate the role of Wnt signalling in specifying, maintaining and directing the differentiation of these progenitors.
Speaker
Val Wilson
Organisation: University of Edinburgh
Travel and Contact Information
Find event
Lecture Theatre
Michael Smith Building
Manchester
