MaRMN Special Seminar: Kristi Kiick (University of Delaware) - 'Phase-separating (Poly)Peptides in the Design of Advanced Biomaterials'
|Starts:||13:00 14 Feb 2020|
|Ends:||14:00 14 Feb 2020|
|What is it:||Seminar|
|Organiser:||Faculty of Biology, Medicine and Health|
|Who is it for:||University staff, Adults, Current University students|
|Speaker:||Kristi L. Kiick|
Phase-separating (Poly)Peptides in the Design of Advanced Biomaterials Kristi L. Kiick, University of Delaware, Department of Materials Science and Engineering
Abstract: Macromolecular structures that are capable of selectively and efficiently engaging cellular targets offer important approaches for mediating biological events and in the development of hybrid materials.
We have employed a combination of biosynthetic tools, bioconjugation strategies, and biomimetic assembly in the design of multiple types of biopolymer conjugates of thermoresponsive (poly)peptides including those derived from sequences of resilin, elastin, and collagen. PEG-biopolymer conjugates have been used in the formation of hydrogels by covalent click-based chemistries that are selectively degradable under pathological conditions.
These materials can be designed to control the release of both small-molecule and macromolecular cargo with tuned release profiles, and materials with select mechanical properties have demonstrated promise for healing vascular graft materials in vivo. The incorporation of (poly)peptides affords materials that not only show controllable micro- and nanoscale morphologies, but that also have promise for targeting drug delivery to damaged tissue.
Kristi L. Kiick
Organisation: University of Delaware, Department of Materials Science and Engineering
Travel and Contact Information
Michael Smith lecture theatre
Michael Smith Building