Prof Nir Gov -- Modelling the migration of branched cells on networks [IN PERSON]
| Dates: | 3 March 2025 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Nir Gov |
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Join us for this seminar by Prof Nir Gov (Weizmann Institute, Israel) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. More details about the joint series can be found here https://northwestseminars.great-site.net/ .
The talk will be hosted in person in room 2.61 of the Simon Building. For those who cannot attend in person the talk will also be streamed via zoom, please contact carl.whitfield@manchester.ac.uk or igor.chernyavsky@manchester.ac.uk for the zoom link, or sign up to the mailing list.
Title: "Modelling the migration of branched cells on networks"
Abstract: Migrating cells often face microenvironmental constraints that force them to extend multiple, often highly dynamic, protrusions, that compete to choose the new direction of motion. This is observed during the migration of immune and cancer cells inside living tissues. However, of how cells coordinate shape dynamics during this directional decision-making (DDM) process is not yet fully understood. We present a coarse-grained theoretical model that allows us to explore the shape dynamics of migrating cells as they perform DDM. We start with cells moving on a single Y-junction, and find that the model predicts deterministic see-saw oscillations between the cellular arms during DDM. This prediction is verified by experiments on sevreal cell types. We next explore the shape dynamics of highly branched cells, and find that cells become less persistent when more branched. This prediction suggests a tradeoff between sensitivity and robustness during migration on complex geomtries, and we compare to observations of cells migrating on patterned substrates. We end by showing the chemotaxis properties of branched-cells, with consequences for immune cells swarming to a wound, as observed for neutrophiles in in-vivo experiments.
To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk
Speaker
Nir Gov
Role: The Lee and William Abramowitz Professorial Chair of Biophysics
Organisation: Weizmann Institute of Science
Travel and Contact Information
Find event
2.61
Simon Building
Manchester
