Advances in Biosciences Seminar Series - Kazuhiro Yamamoto PhD, Institute of Life Course and Medical Sciences, University of Liverpool.
| Dates: | 12 November 2024 |
|---|
| Times: | 13:00 - 14:00 |
|---|
| What is it: | Seminar |
|---|
| Organiser: | Faculty of Biology, Medicine and Health |
|---|
| Who is it for: | University staff |
|---|
| Speaker: | Kazuhiro Yamamoto PhD |
|---|
|
Introducing the first speaker in November for the Advances in Biosciences Seminar Series; Kazuhiro Yamamoto PhD, Institute of Life Course and Medical Sciences, University of Liverpool.
Venue: Michael Smith Lecture Theatre
The seminar will be hosted by Dr Joan Chang
Title “The extracellular molecule clearance system in tissue homeostasis and destruction”
Abstract: Receptor-mediated endocytosis provides a mechanism for the selective uptake of specific molecules thereby controlling the composition of the extracellular environment and biological
processes. My team focus on the low-density lipoprotein receptor–related protein 1 (LRP1), a widely expressed endocytic receptor that mediates clathrin-dependent endocytosis of numerous extracellular molecules. In this seminar, I would like to talk about our original discovery of LRP1-mediated endocytosis of proteolytic enzymes that regulates matrix turnover in articular cartilage and recent findings on its diverse roles in cartilage/bone development, intestinal homeostasis and pulmonary fibrosis.
Speaker Bio: I am a biochemist with a primary interest in regulation of extracellular matrix. After completion of my PhD in Japan, I joined the Kennedy Institute of Rheumatology in 2008, as a postdoctoral research associate, where I started to investigate the mechanisms of cartilage tissue destruction by metalloproteinases. I was awarded Versus Arthritis Career Development Fellowship in 2017, which allowed me to establish my own research group in Liverpool. Recently, I was awarded Versus Arthritis Bridging Fellowship to pursue fundamental research aiming to understand the molecular mechanisms that keep healthy cellular environments in adult tissues.
Speaker
Kazuhiro Yamamoto PhD
Role: Lecturer Institute of Life Course and Medical Sciences
Organisation: University of Liverpool,
Travel and Contact Information
Find event
Michael Smith Lecture Theatre
Michael Smith Building
Manchester
