Andrea Cairoli -- Physical principles of Drosophila abdomen morphogenesis during metamorphosis [IN PERSON]
|Dates:||11 December 2023|
|Times:||14:00 - 15:00|
|What is it:||Seminar|
|Organiser:||Department of Mathematics|
|Who is it for:||University staff, External researchers, Current University students|
Join us for this seminar by Andrea Cairoli (Crick Institute) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. Details of the full series can be found here https://www.cms.livjm.ac.uk/APMSeminar/
The talk will be hosted in person in the Williamson Building, Room G.03. For those who cannot attend in person the talk will also be streamed via zoom, please contact email@example.com or firstname.lastname@example.org for the zoom link, or sign up to the mailing list.
Abstract: Cellular tissues form through self-organized, controlled programs of development relying on feedback between cellular processes, tissue-wide properties, and external cues. This complex interplay is exemplified by the metamorphic program the Drosophila abdominal epidermis undergo during pupal development. Before metamorphosis, histoblasts, progenitor cells of the adult epithelium, live in dormancy within the nests, confined regions in the abdomen located symmetrically to the dorsal midline, and surrounded by the larval epithelium. During metamorphosis, histoblasts proliferate while replacing the larval epidermis, by coordinating the extrusion of larval cells through apoptosis. Histoblasts from the left and right abdominal hemisegments eventually fuse at the midline to finalize the adult epidermis. How the histoblasts regulate their proliferation, divisions and kinetics, and interact with the larval cells to achieve the correct adult abdomen size and the fusion process is largely unknown. In this talk, I will study the morphogenetic process of the abdominal epithelium of Drosophila by reconstructing the spatiotemporal dynamic of cell elongation, area and velocity of the histoblasts and larval cells. I will then recapitulate the experimental observations by formulating a continuum model of the dynamic of the tissue.
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Role: Postdoctoral Training Fellow
Organisation: Francis Crick Institute
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