PSI Seminar with guest speaker Dr. Izzy Jayasinghe
| Dates: | 12 May 2021 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Photon Science Institute |
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| How much: | Free |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Dr. Izzy Jayasinghe |
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Join us for this PSI seminar with guest speaker Dr. Izzy Jayasinghe
In this seminar, Dr. Jayasinghe will outline how the continued improvement and strategic adaptation of super-resolution microscopy tools have enhanced our understanding of the nanoscale structures underpinning life. Dr. Jayasinghe will illustrate some of these advances with examples where super-resolution modalities have allowed us to better-visualise ryanodine receptor (RyR) nanodomains in tissues like the heart, muscle and neural tissues. Correlative structure-function imaging has allowed us to resolve, observe and identify the RyR clustering patterns which spatially-encode the fast calcium signals within the cells. Dr. Jayasinghe will also introduce some of the newer modalities of localisation microscopy that we are developing, such as sandSTORM, which offer a useful workaround some of the key bottlenecks in super-resolution implementation at present.
Speaker
Dr. Izzy Jayasinghe
Organisation: University of Sheffield
Biography: Izzy Jayasinghe is a Senior Research Fellow and a UKRI Future Leader Fellow in the Department of Molecular Biology & Biotechnology in the University of Sheffield. Her research has focused on developing new optical microscopy techniques for studying the organisation of the molecules of life, particularly proteins, within the heart. Currently, she is developing a series of methodologies which enable super-resolution microscopy in the broader Life Sciences such as clinical and environmental research. Her current research focuses on developing more accessible, faster and higher resolution imaging methods for imaging optically-thick (and biologically more complex) samples.
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