Sarah Marzi -- Decoding the Cell Type-Specific Epigenome in Alzheimer’s Disease [IN PERSON]
| Dates: | 2 June 2025 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Sarah Marzi |
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Join us for this seminar by Sarah Marzi (King's) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. More details about the joint series can be found here https://northwestseminars.great-site.net/ .
Title: Decoding the Cell Type-Specific Epigenome in Alzheimer’s Disease
Abstract: Both genetic and epigenetic variation contribute to Alzheimer’s disease (AD) pathology, but their cell type-specific roles in the brain remain unclear. In this talk, I will present how we combine postmortem brain epigenomics with machine learning to understand the regulatory mechanisms underlying AD. First, I will show how deep learning models predict transcription from histone marks across diverse brain cell types and states, revealing that mark function, genomic distance, and cellular context all shape regulatory activity. Next, I will introduce CHAS, a computational tool for inferring cell type-specific histone acetylation from bulk brain data, enabling us to uncover distinct patterns of genetic risk and epigenetic dysregulation across diseases and cell types. Finally, I will share new, unpublished findings from the largest study to date of cell type-specific histone acetylation in AD, offering fresh insight into epigenetic regulation in disease.
The talk will be also be streamed via zoom, please contact carl.whitfield@manchester.ac.uk or igor.chernyavsky@manchester.ac.uk for the zoom link, or sign up to the mailing list.
To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk
Speaker
Sarah Marzi
Role: Senior Lecturer
Organisation: King's College London
Travel and Contact Information
Find event
4.04
Simon Building
Manchester
