Modelling beta band oscillations in the Subthalamic Nucleus - Globus Pallidus network
| Dates: | 19 February 2014 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Alejo Nevado-Holgado |
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This seminar is part of the Neurophysiology Seminar series
Neuronal firing in the basal ganglia - cortex network shows a number of characteristic peaks in its frequency spectrum, most prominently one at beta (20-30Hz) and another at gamma (60-90Hz) bands. While gamma band tends to correlate with the execution of voluntary movement, beta band correlates with the blockade of motor activity or the maintenance of static postures. Additionally, Parkinson's disease (which is characterised by the inability to execute voluntary movements) is accompanied by exacerbated beta band activity in this network. Due to these striking correlations, it is of central importance to elucidate the functional relationship between beta oscillations and motor control. Here, we present one of the basal ganglia models that aim at addressing this question. In this case, the model reproduces the firing rates observed in the subthalamic nucleus - globus pallidus circuit, a basal ganglia sub-network whose architecture is prone to oscillatory activity. Analysis of the model suggests a central role of this sub-network in the exacerbation of beta band in Parkinson disease. Additionally, modelling also suggests the existence of two very different channels travelling through the globus pallidus, a feature which very probably have crucial implications in the processing of motor information through the basal ganglia - cortex network.
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