Arturo Araujo -- Modelling biological first principles to understand clinical outcomes [IN PERSON]
|Dates:||13 March 2023|
|Times:||14:00 - 15:00|
|What is it:||Seminar|
|Organiser:||Department of Mathematics|
|Who is it for:||University staff, External researchers, Current University students|
Join us for this seminar by Arturo Araujo (Roehampton/UCL) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. Details of the full series can be found here https://www.cms.livjm.ac.uk/APMSeminar/
The talk will be hosted in person in the Simon Building, Room 4.38. For those who cannot attend in person the talk will also be streamed via zoom, please contact email@example.com or firstname.lastname@example.org for the zoom link, or sign up to the mailing list.
Abstract: Cell theory, one of the fundamental theories unifying all of biology, states that all cells come from already existing cells, thus making cell division key to homeostasis. Modelling this unifying biological first principle allowed us to examine the complex case of Prostate to Bone Metastasis and its interplay with the bone microenvironment. By modelling the heterogeneity of the disease in terms of changes in cell division, using samples from Mayo Clinic to generate basic biological data, we were able to capture the response of the disease to the standard of care in Moffitt Cancer Centre patients. Furthermore, by utilising differences in cell division under treatment conditions we were able to quantify and forecast the emergence of resistant disease. With this, we aim to discuss the importance of computational modelling, its caveats and limitations, and how to take advantage of this to fill gaps in our basic understanding of the disease and improve clinical outcomes.
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Organisation: University of Roehampton/UCL
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