Neutrophil-vessel Wall Interactions in Vivo: Mode, Mechanisms and Pathogenesis
| Dates: | 19 May 2015 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff |
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| Speaker: | Sussan Nourshargh |
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Migration of leukocytes to sites of injury or inflammation is a crucial component of both innate and adaptive immunity but can also contribute to the pathogenesis of inflammatory disorders. However despite much research there has been a disappointingly slow progress in fruitful targeting of leukocyte trafficking for development of anti-inflammatory drugs, indicating a need for better understanding of the intricacies of targeted pathways. Within our group we aim to investigate the mechanisms of leukocyte transmigration through imaging of inflamed tissues by multiple methods, including the application of high resolution confocal intravital microscopy. With this approach we have characterised the profile and dynamics of leukocyte transmigration through venular walls and as a result have noted previously unreported physiological responses (e.g. sub-endothelial cell crawling1) and have identified potential pathological events such as neutrophil reverse transendothelial cell migration, a response that we have associated with dissemination of systemic inflammation2,3. Such studies have demonstrated that detailed analysis of leukocyte-vessel wall dynamics are likely to identify novel and disease-specific phenomena that could promote a change in thinking towards development of new therapeutic strategies4
Speaker
Sussan Nourshargh
Role: Professor
Organisation: Queen Mary, University of London
Travel and Contact Information
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Michael Smith Lecture Theatre
Michael Smith Building
Manchester
