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A Tale of Two Cycles: circadian rhythms in mammals and respiratory oscillations in yeast

Dates:6 May 2015
Times:13:00 - 14:00
What is it:Seminar
Organiser:Faculty of Life Sciences
Who is it for:University staff
Speaker:Helen Causton
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Circadian rhythms driven by biological clocks are found in across the animal and plant kingdoms and allow an organism to coordinate its internal metabolic state with that of the external environment. Despite the importance and widespread nature of these rhythms and the selective advantage they confer, the primordial mechanism has been hard to dissect as clock proteins do not appear to be conserved, mammalian systems have multiple clocks and few simple model organisms are available. We have shown that short period respiratory oscillations in yeast share a number of properties with circadian rhythms: both are redox cycles interwoven with cellular metabolism that coordinate with the cell division clock. This data points to a common mechanism that drives both ultradian and circadian oscillations and raises questions about the origins of biological timekeeping.

Speaker

Helen Causton

Organisation: Department of Biological Sciences, Columbia University, New York

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Michaal Smith Lecture Theatre
Michael Smith Building
Manchester

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Professor Graham Pavitt

ext. 64477

Graham.Pavitt@manchester.ac.uk

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