Redox Regulation of Chondrocyte Integrin Signaling and Osteoarthritis
|Starts:||13:00 6 Apr 2016|
|Ends:||14:00 6 Apr 2016|
|What is it:||Seminar|
|Organiser:||Faculty of Life Sciences|
|Who is it for:||University staff|
Richard is Director of Basic and Translational Research in the Thurston Arthritis Research Center at Chapel Hill, North Carolina.
Abstract : Osteoarthritis results from degradation of joint tissues including the articular cartilage. Chondrocytes are the only cell type present in cartilage and are responsible for both synthesis and degradation of the cartilage matrix. As the cartilage ECM is degraded, fragments of ECM proteins, including fibronectin fragments that bind the ?5?1 integrin are generated. Unlike intact fibronectin, fibronectin fragments activate cell signaling pathways that upregulate expression of a host of MMPs, cytokines, and chemokines that promote progressive matrix destruction in a positive feedback fashion. Our most recent studies have focused on the redox regulation of chondrocyte signaling through oxidative posttranslational modification of reactive cysteine residues in specific signaling proteins through a process known as protein sulfenylation. These studies are helping to identify key steps in fibronectin fragment-induced signaling that will lead to new targets to stop the progressive destruction of cartilage and other joint tissues in OA.
Role: Director of Basic and Translational Research
Organisation: Thurston Arthritis Research Center at Chapel Hill, North Carolina
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Michael Smith Building