Dynamic models of cellular metabolism – an uncertain perspective
|Starts:||09:00 20 Feb 2014|
|Ends:||10:00 20 Feb 2014|
|What is it:||Seminar|
|Organiser:||Faculty of Life Sciences|
|Who is it for:||University staff, Current University students|
Dynamic models of metabolism are powerful tools to understand cellular biology, develop medical interventions to treat disease, and to help engineering biological systems with new functionalities. The quality of the model predictions depends on the reliability of the kinetic parameter information used to construct the models. However, in contrast to other areas, such as climate modelling, the uncertainty of parameter information is rarely systematically explored in biological models of metabolism. In my talk I will present our work on the explicit incorporation of parameter uncertainty in systems biology and illustrate it using examples from central energy metabolism in protozoan parasites. I will also discuss applications in other areas of systems biology, such as the modelling of signal transduction pathways, and in synthetic biology.
A Gene Regulation and Cellular Biotechnology Science for Breakfast seminar.
Contact Graham Pavitt for further information.
Organisation: Manchester Institute of Biotechnology
Travel and Contact Information
AV Hill Building