Katie Bentley -- Temporal regulation of vascular patterning: in silico, in vitro and in vivo [IN PERSON]
| Dates: | 7 May 2026 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Katie Bentley |
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Join us for this seminar by Katie Bentley (KCL/Crick) as part of the Maths in the Life Sciences seminar series (and the online North West Seminar Series in Mathematical Biology and Data Sciences in collaboration with Liverpool Universities).
A description of the project that Katie will present is provided below.
Though angiogenesis (the growth of new blood vessels from pre-existing ones) must carefully unfold over time to generate functional, well-adapted branching networks, we seldom hear about the time-based properties of angiogenesis, despite timing being central to other areas of biology.
We developed a novel, time-based formulation of endothelial cell behaviour during angiogenesis and through our collection of recent integrated in silico/in vivo studies we have demonstrate that various alterations to cell or tissue conditions act to locally adapt the timing of collective cell decisions and behaviours, impacting when certain cells decide to move, and generating a different spacing of vessel branches in the growing network. We are calling these ‘temporal regulators’ or ‘temporal adaptors’ of blood vessel branch spacing and they represent an exciting potential to externally modulate vessel branching under different conditions. As such we are now investigating them further and their potential as therapeutic targets to normalize vessel growth in disease.
The talk will be also be streamed via Teams, please contact carl.whitfield@manchester.ac.uk or igor.chernyavsky@manchester.ac.uk for the link, or sign up to the mailing list.
To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk
Speaker
Katie Bentley
Role: Reader / Group leader
Organisation: King's College London / The Crick Institute
Travel and Contact Information
Find event
3.62
Simon Building
Manchester
