Plasticity in Differentiation – How do Cells Stahl for Time in the Decision Making Process?
|Starts:||13:00 15 Mar 2016|
|Ends:||14:00 15 Mar 2016|
|What is it:||Seminar|
|Organiser:||Faculty of Life Sciences|
|Who is it for:||University staff, Current University students|
|Speaker:||Professor Joshua Brickman|
Embryonic stem cells (ESCs) are immortal cell lines derived from the peri-implantation mammalian embryo. Both ESCs and the embryos from which they are derived are remarkable, in that individual cells retrain the capacity to begin developmental anew, despite having undergone a degree of patterning or differentiation. What is the basis for this plasticity at a transcriptional level? We have identified two new mechanisms regulating this process. The first involves a protective activity of Polycomb co-repressor complexes, that enables transcriptional up regulation in the absence of commitment. The second relies on the reversible disengagement of RNA PolII from specific promoters in response to signalling. I will discuss these mechanisms and how they impact on the capacity of ESCs to retain their plasticity in self renewal.
Professor Joshua Brickman
Organisation: University of Copenhagen
Travel and Contact Information
Michael Smith Lecture Theatre
Michael Smith Building